Process for making a particulate support matrix for making a rapidly dissolving dosage form
US6207199A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 6, 1998 |
| Grant date | Mar 27, 2001 |
| Priority date | — |
| Expiry date | Jul 6, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2063
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A particulate support matrix, and a dosage form made therefrom, and processes for making such support matrices and dosage forms, which disintegrate or dissolve in a matter of just a few seconds once placed into an aqueous environment. First, a porous particulate powder matrix comprising at least two polymeric components which will serve as the dosage form matrix is produced. The polymeric components have different solubilities. In a second step, a pharmaceutical compound, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In a third step the mixture is formed into a dosage form. Finally, in a fourth step, a coating may be formed upon the outer surface of the dosage form to enhance the intactness and durability of the dosage form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.