Mutations in and genomic structure of HERG--a long QT syndrome gene
US6207383A · kind A · utility
9Cited by
1References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 6, 1999 |
| Grant date | Mar 27, 2001 |
| Priority date | — |
| Expiry date | Jan 6, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to the determination of the genomic structure of HERG which is a gene associated with long QT syndrome. The sequences of the 15 intron/exon junctions has been determined and this information is useful in devising primers for amplifying and sequencing across all of the exons of the gene. This is useful for determining the presence or absence of mutations which are known to cause long QT syndrome. Also disclosed are many new mutations in HERG which have been found to be associated with long QT syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.