Immunoassay reagents and methods for determination of LSD and LSD metabolites
US6207396A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 20, 1998 |
| Grant date | Mar 27, 2001 |
| Priority date | — |
| Expiry date | Feb 20, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/946
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
To improve the detection of LSD in biological samples, antibodies are raised to LSD conjugated to a protein carrier, preferably through the indole ring. Selected antibodies are matched with an immunoassay reagent in which the LSD is conjugated in the same position to a labeling or separation means. The set of reagents can be used in immunoassays with remarkably little cross-reactivity with potential interfering substances such as chlorpromazine and ergotamine, and a low false-positive rate in a panel of clinical test samples. Also provided is a set of reagents for measuring glucuronide metabolites of LSD by immunoassay, which permits exposure to LSD to be determined over a longer diagnostic window.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.