Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy
US6207648A · kind A · utility
31Cited by
12References
54Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 17, 1998 |
| Grant date | Mar 27, 2001 |
| Priority date | — |
| Expiry date | Jul 17, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of killing neoplastic cells are provided. The invention relates to the use of NADPH-cytochrome P450 reductase (RED) gene transfer in combination with cytochrome P450 gene transfer to enhance the sensitivity of tumor cells to anti-cancer drugs that are activated by P450 enzymes. The use of bioreductive drugs that are activated by RED and/or cytochrome P450, in this paradigm, is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.