Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
US6207670A · kind A · utility
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9Claims
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Key dates
| Filing date | Jun 7, 2000 |
| Grant date | Mar 27, 2001 |
| Priority date | — |
| Expiry date | Jun 7, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel derivatives of 5-thia- and 5-selenopyrimidinone are found to inhibit the enzyme glycinamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase (AICARFT). Novel intermediates of these compounds are also disclosed. A novel method of preparing such compounds is also disclosed, as well as methods and compositions for employing the compounds as antiproliferative agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.