Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use
US6207684A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 2, 1999 |
| Grant date | Mar 27, 2001 |
| Priority date | — |
| Expiry date | Dec 2, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/4535
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to methods of treatment of ocular disease states, modulated by histaminergic and inflammatory mechanisms in a mammal using norketotifen, 10-OH-norketotifen and pharmaceutical compositions of those compounds. More particularly, this invention relates to methods of treating ocular diseases (such as, seasonal allergic conjunctivitis and other forms of conjunctivitis, keratitis, hyperemia, cellular infiltration, vascularization, fibroblastic proliferation, inflammatory cell degranulation), while avoiding certain side effects, such as local irriation, using compounds with combined antihistaminic and mast cell stabilizing activities.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.