Process for the preparation of arylmetal compounds and their reaction with electrophilic reagents

US6207835A · kind A · utility

Assignee

• MERCK KGAA · DE

Inventors

• Volker Reiffenrath · Roßdorf, DE
• Hans Christian Stiasny · Griesheim, DE

Key dates

• Filing date: Dec 17, 1999
• Grant date: Mar 27, 2001
• Expiry date: Dec 17, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F1/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Arylmetal compounds are prepared by deprotonation of aromatics which have a hydrogen atom in the ortho position relative to a halogen atom or a trifluoromethoxy group, using a suitable base or by halogen-metal exchange of haloaromatics using a suitable metalating reagent. The arylmetal compounds are prepared in a continuous-flow reactor. The arylmetal compound can be further reacted with an electrophilic reagent.