Non-linear optical tomography of turbid media
US6208886A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 3, 1998 |
| Grant date | Mar 27, 2001 |
| Priority date | — |
| Expiry date | Apr 3, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/4519
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
An apparatus utilizing non-linear optical signals for use in constructing a three-dimensional tomographic map of an in vivo biological tissue for medical disease detection purposes. In one embodiment, said apparatus comprises a stage for supporting the in vivo biological tissue; a laser for illuminating the in vivo biological tissue with a focused beam of laser light, the light emerging from the in vivo biological tissue comprising fundamental light, harmonic wave light, and fluorescence due to multi-photon excitation; a filter for selectively passing only at least one of the harmonic wave light and the fluorescence; one or more detectors for individually detecting each of the harmonic wave light and the fluorescence selectively passed; and a mechanism for moving the laser relative to the stage in x, y and z directions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.