Site-specific 13C-enriched reagents for diagnostic medicine by magnetic resonance imaging
US6210655A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 18, 1997 |
| Grant date | Apr 3, 2001 |
| Priority date | — |
| Expiry date | Jun 18, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to site-specific .sup.13 C-enriched reagents for diagnostic medicine for magnetic resonance imaging. The site-specific .sup.13 C-enriched reagents may be represented by the formula: T-L-R. T is a site-specific targeting group which selectively binds to a disease-related target in an animal or human, R is an inert polymer containing repeating .sup.13 C reporting groups which provide a magnetic resonance imaging signal, and L is a linker group which connects the site-specific targeting group to the inert polymer. The site-specific .sup.13 C-enriched reagents are targeted to and capable of identifying, quantifying, and localizing disease-specific loci, such as blood clots, .beta.-amyloid plaques of Alzheimer's disease, and tumors through the use of magnetic resonance imaging. The present invention also pertains to a method for employing the site-specific .sup.13 C-enriched reagents in a living mammal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.