Identification of canine leukocyte adhesion deficiency in dogs
US6210897A · kind A · utility
Inventors
Key dates
| Filing date | Sep 10, 1999 |
| Grant date | Apr 3, 2001 |
| Priority date | — |
| Expiry date | Sep 10, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to an isolated nucleic acid molecule encoding canine leukocyte integrin .beta.-2 subunit having a Cys36Ser missense mutation, wherein the missense mutation is indicative of a carrier of canine leukocyte adhesion deficiency. The present invention also relates to a method for identifying dogs which are carriers of or are affected with canine leukocyte adhesion deficiency. This method includes obtaining a biological sample from a dog and testing the biological sample for a Cys36Ser missense mutation in a gene encoding leukocyte integrin .beta.-2 subunit, wherein the missense mutation in one allele is indicative of a carrier of canine leukocyte adhesion deficiency and the missense mutation in both alleles is indicative of a dog affected with canine leukocyte adhesion deficiency.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.