Method to identify proteins which bind to integrin regulatory proteins
US6210914A · kind A · utility
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2Claims
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Key dates
| Filing date | Feb 13, 1998 |
| Grant date | Apr 3, 2001 |
| Priority date | — |
| Expiry date | Feb 13, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides purified and isolated polynucleotides encoding IRP (Integrin Regulatory Protein) polypeptides which regulate .beta..sub.2 and .beta..sub.7 integrins and which are contemplated to participate in integrin signaling and/or recycling pathways. Also provided are methods for identifying modulators of IRP activities and methods for identifying other proteins which interact with IRP polypeptides in signaling pathways. Modulators of IRP interactions are contemplated to be useful, for example, in monitoring and treating inflammatory processes involving leukocytes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.