Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents

US6211158A · kind A · utility

Assignee

• Roche Diagnostics GMBH · DE

Inventors

• Frank Seela · Osnabrück, DE
• Heinz-Peter Muth · Osnabrück, DE
• Klaus Kaiser · Neustadt, DE
• Werner Bourgeois · Osnabrück, DE
• Klaus Muhlegger · Polling, DE
• Herbert von der Eltz · Spaichingen, DE
• Hans-Georg Batz · Tutzing, DE

Key dates

• Filing date: Jun 26, 1992
• Grant date: Apr 3, 2001
• Expiry date: Jun 26, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides desazapurine-nucleoside derivatives of the general formula: ##STR1## wherein X is a nitrogen atom or a methine radical, W is a nitrogen atom or a C--R.sup.4 radical, R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which can be the same or different, are hydrogen or halogen atoms, hydroxyl or mercapto groups, lower alkyl, lower alkylthio, lower alkoxy, aralkyl, aralkoxy or aryloxy radicals or amino groups optionally substituted once or twice, R.sup.5 is a hydrogen atom or a hydroxyl group, R.sup.6 and R.sup.7 are each hydrogen atoms or one of them is a halogen atom or a cyano or azido group or an amino group optionally substituted once or twice, whereby one of R.sup.6 and R.sup.7 can also be a hydroxyl group when X is a methine radical and, in addition, R.sup.5 and R.sup.7 can together also represent a further valency bond between C-2' and C-3' and Y is a hydrogen atom or a mono-, di- or tri-phosphate group.