UDP-N-acetylmuramoyl-l-alanine:D-glutamate ligase (MURD) of staphylococcus aureus

US6211161A · kind A · utility

Assignees

• The Brigham and Women's Hospital, Inc. · US
• Virus Research Institute · US
• SmithKline Beecham Limited · US
• SmithKline Beeacham P.L.C. · GB

Inventors

• David T Beattie · Boston, US
• Robert L Deresiewicz · Boston, US
• Adrian M Lowe · Watertown, US
• Richard Oakley Nicholas · Collegeville, US
• Leslie Marie Palmer · Audubon, US
• Julie M Pratt · Wigston, GB
• Michael Arthur Lonetto · Collegeville, US
• John Edward Hodgson · Malvern, US

Key dates

• Filing date: Mar 19, 1999
• Grant date: Apr 3, 2001
• Expiry date: Mar 19, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/31
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides murD polypeptides and polynucleotides encoding murD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing murD polypeptides to screen for antibacterial compounds.