Antisense oligonucleotides of the human chk1 gene and uses thereof
US6211164A · kind A · utility
12Cited by
0References
9Claims
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Assignee
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Key dates
| Filing date | Mar 10, 2000 |
| Grant date | Apr 3, 2001 |
| Priority date | — |
| Expiry date | Mar 10, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/111
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject invention relates to antisense oligonucleotides of the human Chk1 gene and to uses thereof. The human ChK1 gene is a major G2/M checkpoint gene that is activated in response to DNA damage. In particular, the gene transduces the inhibitory signal from DNA damage sensors to the basic cell cycle machinery. Thus, antisense oligonucleotides to the human Chk1 gene may be used, for example, to inhibit the gene thereby preventing G2 arrest induced by DNA damaging agents. Such antisense oligonucleotides should also further sensitize tumor cells thereby making them more sensitive to therapy than normal cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.