Azetidinone derivatives for the treatment of HCMV infections
US6211170A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 1998 |
| Grant date | Apr 3, 2001 |
| Priority date | — |
| Expiry date | Oct 6, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of formula I: ##STR1## wherein R.sub.1 is hydrogen, methyl, ethyl, methoxy or methylthio; R.sub.2 and R.sub.3 each independently is hydrogen or C.sub.1-3 alkyl; R.sub.4 is hydrogen, lower alkyl, methoxy, ethoxy, or benzyloxy; R.sub.5 is lower alkyl, lower cycloalkyl, (CH.sub.2).sub.m C(O)OR.sub.6 wherein m is the integer 1 or 2 and R.sub.6 is lower alkyl, phenyl optionally substituted with C(O)OR.sub.7 wherein R.sub.7 is lower alkyl or phenyl (lower alkyl); or R.sub.6 is Het or Het(lower alkyl; or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a nitrogen containing ring optionally substituted with benzyloxycarbonyl or with phenyl optionally substituted among other group with C(O)OR.sub.7 wherein R.sub.7 is lower alkyl or (lower alkyl)phenyl; X is selected from the group consisting of O, S, SO, SO.sub.2, NR.sub.8, wherein R.sub.8 is H or lower alkyl; and PA0 Y is C.sub.1-10 non-cyclic or cyclic alkyl; [(CH.sub.2).sub.0-1 ]-phenyl, said phenyl ring optionally substituted; Het or Het(lower alkyl); or when X is NR.sub.8, wherein R.sub.8 is lower alkyl and Y is lower alkyl or lower alkoxy, X and Y are joined together to form a morpholino o…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.