1-Benzenesulfonyl pyrrolidine derivatives as bradykinin receptor antagonists
US6211181A · kind A · utility
1Cited by
1References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 27, 1999 |
| Grant date | Apr 3, 2001 |
| Priority date | — |
| Expiry date | Oct 27, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to compounds of the formula ##STR1## where X is halogen, R.sub.1 is H or a C.sub.1 -C.sub.3 alkyl, R.sub.2 is H or OH and R.sub.3 is one of ##STR2## in which A is a single bond or a --CO(CH.sub.2).sub.p --NH-- group, R.sub.4 is H or --C(.dbd.NR.sub.5)NHR'.sub.5, R.sub.5 and R'.sub.5 are each H or a C.sub.1 -C.sub.6 alkyl group, R.sub.6 is H or a C.sub.1 -C.sub.3 alkyl group, m is 0, 1 or 2; n is 2, 3 or 4; p is 1, 2 or 3; plus their acid addition salts. The invention likewise relates to the method for their preparation and their therapeutic applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.