Compounds useful for inhibition of farnesyl protein transferase
US6211193A · kind A · utility
15Cited by
17References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 15, 1998 |
| Grant date | Apr 3, 2001 |
| Priority date | — |
| Expiry date | Jun 15, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compounds of the formula: ##STR1## are disclosed. In Formula 1.0 a represents N or NO, R.sup.1 and R.sup.3 are halo, R.sup.2 and R.sup.4 are independently H or halo provided that at least one is H, X is C, CH or N, and R represents a cycloalkyl or a heterocycloalkyl ring that is substitued. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.