Substituted phenyl compounds
US6211234A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 27, 1997 |
| Grant date | Apr 3, 2001 |
| Priority date | — |
| Expiry date | Jun 27, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
##STR1## Compounds of formula (I) are described wherein R.sup.1 is hydrogen, -(lower alkyl).sub.q (CO.sub.2 R.sup.6 or OH), --CN, --C(R.sup.7).dbd.NOR.sup.8, NO.sub.2, --O(lower alkyl)R.sup.9, --C.tbd.C--R.sup.10, --CR.sup.11.dbd.C(R.sup.12)(R.sup.13), --C(.dbd.O)CH.sub.2 C(.dbd.O)CO.sub.2 H, --CO(R.sup.14), alkylthio, alkylsulphinyl, alkylsulphonyl, carbamoyl, thiocarbamoyl, substituted carbamoyl, substituted thiocarbamoyl, sulphamoyl or an optionally substituted nitrogen-containing ring, m, n, o and p are independently zero or 1 and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are various groups; and physiologically acceptable salts, N-oxides and prodrugs thereof. The compounds have endothelin antagonist activity and are useful as pharmaceuticals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.