Methods of Synthesing Purine Compounds Having PDE Iv Inhibitory Activity

US6211367A · kind A · utility

Assignee

• Euro-Celtique S.A. · LU

Inventors

• David Cavalla · Cambridge, GB
• Mark Chasin · Manalapan, US
• Peter Hofer · Liestal, CH

Key dates

• Filing date: Dec 11, 1998
• Grant date: Apr 3, 2001
• Expiry date: Dec 11, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention comprises compounds having the general formula I: ##STR1## wherein: PA1 Y, is N or CH PA1 Z is selected from the group consisting of alkyl groups such as alkylene groups such as CH.sub.2, CH.sub.2 CH.sub.2, CH(CH.sub.3); alkenyl groups such as CH.dbd.CH; alkynyl groups such as C.tbd.C; and NH, N(C.sub.1 -C.sub.3 alkyl), O, S, C(O)CH.sub.2 and OCH.sub.2 ; PA1 R.sup.1 and R.sup.2 are selected from the group consisting of hydrogen and a C.sub.1 -C.sub.8 straight or branched alkyl or a C.sub.3 -C.sub.8 cycloalkyl; PA1 R.sup.3 is a C.sub.3 -C.sub.12 straight or branched alkyl; PA1 R.sup.4 is a C.sub.3 -C.sub.10 cycloalkyl optionally substituted with OH or C.sub.3 -C.sub.10 cycloalkenyl optionally substituted with OH; and PA1 R.sup.8 is a C.sub.1 -C.sub.8 straight or branched alkyl or a C.sub.3 -C.sub.8 cycloalkyl, optionally substituted with OH; PA1 and methods of synthesis.