Phenyl urea antagonists of the IL-8 receptor

US6211373A · kind A · utility

Assignee

• SmithKline Beecham Limited · US

Inventors

• Katherine L. Widdowson · King of Prussia, US
• Daniel F. Veber · Ambler, US
• Anthony Joseph Jurewicz · Royersford, US
• Robert Philip Hertzberg · Downingtown, US
• Melvin Clarence Rutledge, Jr. · Lansdale, US

Key dates

• Filing date: Jul 8, 1998
• Grant date: Apr 3, 2001
• Expiry date: Jul 8, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to novel compounds of Formula (I), and a novel use of these compounds in treating chemokine mediated diseases, wherein the chemokine binds to an IL-8 a or b receptor. Compounds of Formula (1) are represented by the structure: ##STR1## PA1 wherein interalia, X is oxygen or sulfur; PA1 R is any functional moiety having an ionizable hydrogen and a pKa of 10 or less; PA1 R.sub.1 is independently selected from hydrogen; halogen; nitro; cyano; C.sub.1 -C.sub.10 alkyl; halosubstituted C.sub.1-10 alkyl; C.sub.2-10 alkenyl; C.sub.1-10 alkoxy; halosubstituted C.sub.1-10 alkoxy; azide; (CR.sub.8 R.sub.8).sub.q S(O).sub.t R.sub.4 ; hydroxy; hydroxy substituted C.sub.1-4 alkyl; aryl; aryl C.sub.1-4 alkyl; aryl C.sub.2-10 alkenyl; aryloxy; aryl C.sub.1-4 alkyloxy; heteroaryl; heteroarylalkyl; heteroaryl C.sub.2-10 alkenyl; heteroaryl C.sub.1-4 alkyloxy; heterocyclic, heterocyclic C.sub.1-4 alkyl; heterocyclic C.sub.1-4 alkyloxy; heterocyclic C.sub.2-10 alkenyl; PA1 q is 0 or an integer having a value of 1 to 10; n is an integer having a value of 1 to 3; PA1 m is an integer having a value of 1 to 3; PA1 n is an integer having a value of 1 to 3; PA1 Y is hydrogen; halogen; n…