Thiazole compounds

US6211381A · kind A · utility

Assignee

• Novartis Crop Protection, Inc. · US

Inventors

• Henry Szczepanski · Möhlin, CH
• Thomas Gobel · Lörrach, DE
• Ottmar Franz Huter · Bad Kötzting, DE
• Anthony Cornelius O'Sullivan · Basel, CH
• Marcel Senn · Basel, CH
• Thomas Rapold · Laufenburg, CH
• Peter Maienfisch · Aesch, CH
• Thomas Pitterna · Chur, CH

Key dates

• Filing date: Jun 1, 1998
• Grant date: Apr 3, 2001
• Expiry date: Jun 1, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for preparing a compound of formula (I), in which X is CH or N, Y is NO.sub.2 or CN, Z is CHR.sub.3, O, NR.sub.3 or S, R.sub.1 and R.sub.2 are either each, independently of the other, hydrogen or unsubstituted or R.sub.4 -substituted alkyl or together a two- or three-membered alkylene bridge or a two- or three-membered alkylene bridge in which one member is replaced by a hetero member selected from the group, consisting of NR.sub.5, O and S, R.sub.3 is H or unsubstituted or R.sub.4 -substituted alkyl, R.sub.4 is an unsubstituted or substituted aryl or heteroaryl group, and R.sub.5 is H or alkyl, which comprises a) reacting a compound of formula (II) with a chlorinating agent or b1) initially reacting a compound of formula (IV) with a compound of formula (V) and b2) further reacting the compound of formula (II) obtainable thereby, with or without intermediate isolation, with a chlorinating agent, to intermediates used in this process, to the use of these intermediates and to a process for the preparation of these intermediates.