Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
US6214054A · kind A · utility
74Cited by
8References
56Claims
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Key dates
| Filing date | Sep 21, 1998 |
| Grant date | Apr 10, 2001 |
| Priority date | — |
| Expiry date | Sep 21, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/92
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to terminal sterilization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.