Di-enzymatic treatment of outer ear infection in dogs and cats
US6214339A · kind A · utility
Inventor
Key dates
| Filing date | Jan 12, 2000 |
| Grant date | Apr 10, 2001 |
| Priority date | — |
| Expiry date | Jan 12, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/47
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Otitis externa is treated in dogs and cats by administering to the outer ear of the infected animal a dosage, effective to alleviate the symptoms of the infection, of a substantially non-aqueous, di-enzymatic therapeutic composition, in a liquid or gel fluid carrier. The composition contains an oxidizable substrate and an oxidoreductase enzyme specific to such substrate for producing hydrogen peroxide upon encountering the environment of the outer ear and further contains an iodide salt and and a peroxidatic peroxidase for interacting with the hydrogen peroxide to produce a hypoiodite biocidal agent. Any unbound water present in the composition is limited to an amount not more than about 1.0 wt. % to stabilize the composition against the production of hydrogen peroxide prior to aural application of the composition to enhance efficacy of treatment. An illustrative di-enzymatic composition composition contains glucose, glucose oxidase, potassium iodide and lactoperoxidase in a fluid mixture of glycerol and propylene glycol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.