Physiologically active substance sulphostin, process for producing the same, and use thereof

US6214340A · kind A · utility

Assignee

• Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai · JP

Inventors

• Tomio Takeuchi · Tokyo, JP
• Masa Hamada · Hoya, DE
• Yasuhiko Muraoka · Tokyo, JP
• Tetsuo Akiyama · Tokyo, JP
• Masatoshi Abe · Tokyo, JP
• Hiroshi Naganawa · Tokyo, JP
• Yoshikazu Takahashi · Nagoya, JP

Key dates

• Filing date: May 12, 2000
• Grant date: Apr 10, 2001
• Expiry date: May 12, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/465
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides a physiologically active substance having a strong dipeptidyl peptidase IV inhibitory activity. The physiologically active substance sulphostin is obtained by culturing a microorganism belonging to the genus Streptomyces and having an ability to produce the physiologically active substance sulphostin, producing and accumulating this substance in the cultures, and harvesting it from the cultures.