Method of identifying modulators of protein tyrosine phosphatase activity
US6214564A · kind A · utility
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6Claims
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Key dates
| Filing date | Sep 22, 1998 |
| Grant date | Apr 10, 2001 |
| Priority date | — |
| Expiry date | Sep 22, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/42
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A human protein tyrosine phosphatase (PTP) has been identified and its cDNA has been isolated. This PTP, denoted PTP-OB, has a receptor-like three dimensional structure and is present in osteoblasts. PTP-OB is involved in osteoblast differentiation, and modulators of PTP-OB activity in turn modulate osteoblast differentiation, osteoclast differentiation and osteoclast activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.