Acyclovir diester derivatives

US6214811A · kind A · utility

Assignee

• Drug Innovation & Design, Incorporated · US

Inventors

• Arnold Glazier · Newton, US
• Milka Yanachkova · Newton, US
• Ivan Yanachkov · Newton, US

Key dates

• Filing date: Feb 28, 2000
• Grant date: Apr 10, 2001
• Expiry date: Feb 28, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are novel prodrugs represented by the following structural formula; ##STR1## Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.