Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

US6214827A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Adriano Afonso · West Caldwell, US
• John J. Baldwin · Gwynedd Valley, US
• Ronald J. Doll · Maplewood, US
• Ge Li · Shanghai, CN
• Alan K. Mallams · Hackettstown, US
• F. George Njoroge · Hackettstown, US
• Dinanath F. Rane · Morganville, US
• John Charles Reader · Princeton, US
• Randall R. Rossman · Nutley, US

Key dates

• Filing date: Jun 23, 1998
• Grant date: Apr 10, 2001
• Expiry date: Jun 23, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.