Caspases and apoptosis
US6214858A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 9, 1999 |
| Grant date | Apr 10, 2001 |
| Priority date | — |
| Expiry date | Dec 9, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of formula ##STR1## wherein PA1 R.sub.1 is hydrogen, or C.sub.1-4 alkyl; PA1 R.sub.2 is C.sub.1-10 alkyl, optionally substituted arylC.sub.1-4 alkyl, optionally substituted heteroaryl C.sub.1-4 alkyl optionally substituted C.sub.3-7 cycloalkyl, or R.sub.1 and R.sub.2 together with the nitrogen to which they are attached from a 3 to 10 membered ring which optionally contains an aditional heteroatom selected from oxygen, nitrogen or sulfur, PA1 R.sub.3 and R.sub.4 are C.sub.1-6 alkyl, hydrogen, nitro, or halogen and PA1 R.sub.5 is C.sub.1-6 alkyl, hydrogen, arylalkyl or heteroarylalkyl. The present invention is to the novel compounds of Formula (I), their pharmaceutical compositions, and to the novel inhibition of Caspases for use in the treatment of apoptosis, and disease states caused by excessive or inappropriate cell death.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.