2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia

US6214877A · kind A · utility

Inventors

• John A. Butera · Clarksburg, US
• Craig E. Caufield · Plainsboro, US
• Russell Graceffa · Hampton, US
• Alexander Greenfield · Plainsboro, US
• Eric Gould Gundersen · Royersford, US
• Lisa Marie Havran · Bordentown, US
• Alan H. Katz · Lawrenceville, US
• Joseph R. Lennox · Morrisville, US
• Scott Mayer · Lawrence, US
• Robert E. McDevitt · Somerville, US

Key dates

• Filing date: May 10, 1999
• Grant date: Apr 10, 2001
• Expiry date: May 10, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides compounds of Formula I having the structure ##STR1## wherein: PA0 B, C, D, and R.sup.1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.