Allosteric inhibitors of pyruvate kinase
US6214879A · kind A · utility
31Cited by
2References
3Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 24, 1998 |
| Grant date | Apr 10, 2001 |
| Priority date | — |
| Expiry date | Mar 24, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/325
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Chemical structures have been identified which allosterically modify pyrvate kinase and either inhibit or activate enzymatic activity. These compounds can be used as pharmaceuticals in the treatment of a wide variety of diseases and disorders where influencing metabolic processes is beneficial, such as the glycolytic pathway, all pathways which use ATP as an energy source, and all pathways which involve 2,3-diphosphoglycerate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.