Reshaped human antibody to human medulloblastoma cells
US6214973A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 9, 1996 |
| Grant date | Apr 10, 2001 |
| Priority date | — |
| Expiry date | Sep 9, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses reshaped antibody to human medulloblastoma cells comprising: PA0 (A) an L chain comprising: PA1 (1) a human L chain C region, and PA1 (2) an L chain V region comprising human L chain FRs and L chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells; and, PA0 (B) an H chain containing: PA1 (1) a human H chain C region, and PA1 (2) an H chain V region comprising human H chain FRs and H chain CDRs of mouse monoclonal antibody ONS-M21 to human medulloblastoma cells. Since the majority of this reshaped human antibody is derived from a human antibody and mouse CDRs have a low level of antigenicity, the reshaped human antibody of the present invention has a low level of antigenicity in humans, and is therefore expected to be useful as a therapeutic agent and diagnostic tool for brain tumors such as medulloblastoma which strongly express antigen that is recognized by this antibody.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.