Trifluoromethylating reagents and synthesizing processes
US6215021A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 17, 1999 |
| Grant date | Apr 10, 2001 |
| Priority date | — |
| Expiry date | Jun 17, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C381/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A family of electrophilic trifluoromethylating reagents which can be synthesized by comparatively simple, inexpensive routes, and for which the reactivity can be varied according to need. A composition of matter according to the first embodiment of the invention comprises a compound having the formula: ##STR1## in which A comprises H or F and B comprises F, SCF.sub.3, OCF.sub.3, OCHF.sub.2, S.sup.+ (CF.sub.3)C.sub.6 H.sub.5, NO.sub.2 or an NO.sub.2 substituent. In a second embodiment of the invention, a process for preparing a trifluoromethyl diphenylsulfonium triflate compound corresponding to the formula shown above comprises reacting phenyl trifluoromethyl sulfoxide or one of its derivatives with an aromatic compound in which A comprises H or F and B comprises H, F, SCF.sub.3, OCF.sub.3, OCHF.sub.2, S.sup.+ (CF.sub.3)C.sub.6 H.sub.5, NO.sub.2 or an NO.sub.2 substituent. In a third embodiment of the invention, a trifluoromethylation process comprises reacting a trifluoromethyl diphenylsulfonium triflate corresponding to the formula shown above with an electron rich substrate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.