Retroviral packaging cell line
US6218181A · kind A · utility
61Cited by
12References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 3, 1998 |
| Grant date | Apr 17, 2001 |
| Priority date | — |
| Expiry date | Sep 3, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/20222
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides packaging cell lines and recombinant lentiviral or retroviral particles produced therefrom, particularly pseudotyped retroviral particles. The packaging cell lines of the invention are produced by inducibly expressing an envelope protein by methods described herein. Also described is a screening assay for compounds that affect integration of viral nucleic acid into target (e.g., host) nucleic acid. Such compounds are identified based on their effect on viral integrase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.