Lantibiotic from Streptococcus mutans and uses thereof
US6218362A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 8, 1997 |
| Grant date | Apr 17, 2001 |
| Priority date | — |
| Expiry date | Sep 8, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Mutacin are bactericidal substances of proteinaceous natures produced by Streptococcus mutans. Lantibiotics are antibacterial substances containing posttranslationnally modified amino acids such as lanthionine. The present invention teaches a simple method of purifying mutacin B-Ny266 from Streptococcus mutans strain Ny266 to homogeneity. The present invention further teaches the primary amino acid sequence of mutacin B-Ny266 as well as its proposed modified structure. Further, the present invention teaches compositions comprising mutacin B-Ny266 as well as methods for the treatment and/or prophylaxy of bacterial infections comprising an administration of a suitable dose of composition comprising mutacin B-Ny266.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.