Anthranilic acid derivatives as multi drug resistance modulators
US6218393A · kind A · utility
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Key dates
| Filing date | Jun 9, 1999 |
| Grant date | Apr 17, 2001 |
| Priority date | — |
| Expiry date | Jun 9, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Anthranilic acids of formula (I): ##STR1## wherein each of R to R.sup.9 is an organic substituent, n is 0 or 1, m is 0 or an integer of 1 to 6, q is 0 or 1, X is a direct bond, O, S, --S--(CH.sub.2).sub.p or --O--(CHO.sub.2).sub.p -- wherein p is from 1 to 6 and Ar is an unsaturated carbocyclic or heterocyclic group, and the pharmaceutically acceptable salts thereof, have activity as inhibitors of P-glycoprotein and may thus be used, inter alia, as modulators of multidrug resistance in the treatment of multidrug resistant cancers, for example to potentiate the cytotoxicity of a cancer drug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.