Patent · US Expired

Acetylcholine enhancers

US6218402A · kind A · utility

3Cited by

3References

4Claims

0Family size

Assignees

Arena Pharmaceuticals, Inc. · US
S.S.P. INC. · JP

Inventors

Derek T. Chalmers · Solana Beach, US
Susumo Sato · Chiba, JP
Tadayuki Koda · Chiba, JP

Key dates

Filing date	Jun 9, 1999
Grant date	Apr 17, 2001
Priority date	—
Expiry date	Jun 9, 2019

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are quinoline derivatives having dual mechanistic properties, referred to in this patent document as "acetylcholine enhancers", i.e., compounds which evidence acetylcholinesterase (AChE) inhibition activity, and 5-HT3 receptor antagonist activity. A particularly preferred compound is 2-[2-(1-benzylpiperizin-4-yl) ethyl]-2,3-dihydro-9-methoxy-1H-pyrrolo [3,4-b] quinolin-1-one hemifumarate, referred to herein as Compound A ("Cm.A").

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.