3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents

US6218418A · kind A · utility

Assignees

• Pharmacia & Upjohn S.p.A. · IT
• Pharmacia & Upjohn Company LLC · US

Inventors

• Paolo Pevarello · Pavia, IT
• Paolo Orsini · Legnano, IT
• Gabriella Traquandi · Milano, IT
• Mario Varasi · Milano, IT
• Edward L. Fritzen · Niantic, US
• Martha A. Warpehoski · Portage, US
• Betsy Susan Pierce · Kalamazoo, US
• Maria Gabriella Brasca · Cusago, IT

Key dates

• Filing date: Sep 22, 2000
• Grant date: Apr 17, 2001
• Expiry date: Sep 22, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds which are 3-amino-pyrazole derivatives represented by formula (I): ##STR1## where PA1 R is a C.sub.3 -C.sub.6 cycloalkyl group, which may optionally be substituted by a straight or branched C.sub.1 -C.sub.6 alkyl group, and PA1 R.sub.1 is a straight or branched C.sub.1 -C.sub.6 alkyl group or a C.sub.2 -C.sub.4 alkenyl, cycloalkyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl and arylalkenyl, which may be optionally substituted; or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.