Substituted biphenyls

US6218431A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• William R. Schoen · Edison, US
• Gaetan Ladouceur · Guilford, US
• James H. Cook, II · East Hampton, US
• Timothy G. Lease · Corona, US
• Donald J. Wolanin · Orange, US
• Richard H. Kramss · Stamford, US
• Donald L. Hertzog · Cambridge, US
• Martin Osterhout · Raleigh, US

Key dates

• Filing date: Jul 31, 1997
• Grant date: Apr 17, 2001
• Expiry date: Jul 31, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted biphenyls having glucagon receptor antagonistic activity. Claimed compounds have the formula ##STR1## wherein PA1 R.sup.1a and R.sup.1b independently represent (C.sub.1 -C.sub.6) alkyl; R.sup.2 represents (C.sub.1 -C.sub.10) alkyl or substituted (C.sub.1 -C.sub.10) alkyl wherein the substituents are independently from 1 to 3 of --SR.sup.7 ; R.sup.7 represents phenyl, or substituted phenyl wherein the substituents are independently 1-5 of halogen, trifluoromethyl, (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.6) alkoxy, nitro, cyano, or hydroxyl; R.sup.3 represents substituted (C.sub.1 -C.sub.6) alkyl wherein the substituents are 1-2 hydroxyl groups; G represents a substituent selected from the group consisting of halogen, (C.sub.1 -C.sub.6) alkyl, and OR.sup.4 wherein R.sup.4 is H or (C.sub.1 -C.sub.6) alkyl; and y is 0 or an integer of 1-3. Pharmaceutical compositions containing such compounds and methods of treatment of glucagon-mediated conditions by administering such compounds are also claimed.