Compounds and methods for the selective treatment of cancer and bacterial infections
US6218519A · kind A · utility
90Cited by
3References
44Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1996 |
| Grant date | Apr 17, 2001 |
| Priority date | — |
| Expiry date | Apr 12, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/252
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to compounds containing an anthracyclinone group such as doxorubicin, daunorubicin or a derivative thereof. The compounds of the invention also contain ester, glycoside or glucuronide structures which are hydrolyzed by the corresponding esterase, glycosidase or glucuronidase. These compounds possess potent cytotoxic activity which is developed after the hydrolysis of the ester or glycoside group of the compound and are effective in the inhibition of tumor cells and bacterial growth after activation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.