Structure and expression of the biotin carboxylase subunit of heteromeric acetyl-CoA carboxylase
US6218600A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 12, 1996 |
| Grant date | Apr 17, 2001 |
| Priority date | — |
| Expiry date | Jun 12, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/8247
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The gene encoding a biotin carboxylase subunit of heteromeric ACCase has been isolated and sequenced. The cDNA sequence and deduced amino acid sequence is set forth in FIG. 1 and has been accorded GenBank Accession No. L38260. By controlling expression of the gene of the present invention, carboxylation of acetyl-CoA to produce malonyl-CoA may be controlled. Thus, by introducing constructs of the gene of the present invention in sense or anti-sense orientation, carboxylation of acetyl-CoA to produce malonyl-CoA may be increased or decreased. Consequently, fatty acid synthesis in plants and seeds which depends on malonyl-CoA in the plastid may also be controlled.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.