Metal complexes derivatized with folate for use in diagnostic and therapeutic applications

US6221334A · kind A · utility

Assignee

• BRACCO RESEARCH S.A. · CH

Inventors

• Paul W. Wedeking · Cranbury, US
• Ruth E. Wager · Rockville, US
• Thangavel Arunachalam · Plainsboro, US
• Kondareddiar Ramalingam
• Karen E. Linder · Kingston, US
• Ramachandran Ranganathan · Princeton, US
• Adrian D. Nunn · Lambertville, US
• Natarajan Raju · Kendall Park, US
• Michael F. Tweedle · Princeton, US

Key dates

• Filing date: Jan 3, 2000
• Grant date: Apr 24, 2001
• Expiry date: Jan 3, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.