Pseudoceramides, and dermatologic external preparations containing the same
US6221371A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 10, 1999 |
| Grant date | Apr 24, 2001 |
| Priority date | — |
| Expiry date | May 10, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q19/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to pseudoceramide derivatives represented by formula(I) or (II): EQU R.sub.1 --COCHR.sub.2 CONR.sub.3 R.sub.4 (I) EQU R.sub.1 --CH(OH)CHR.sub.2 CONR.sub.3 R.sub.4 (II) wherein, each of R.sub.1 and R.sub.2 represents linear or branched alkyl group or alkenyl group having 6.about.22 carbon atoms; each of R.sub.3 and R.sub.4 represents hydrogen, methyl, ethyl, propyl, or linear or branched C.sub.2.about.C.sub.6 alkyl group having one or more hydroxyl group(s), or monosaccharide, a process for preparing the same, and dermatologic external preparations containing the same. When the pseudoceramide derivatives according to the present invention are applied in an dermatologic external preparations the moisture-retaining property and resilience of skin and hair is enhanced such so that the derivatives are useful in protection of skin-aging. In addition, the derivatives are useful for inducing the formation of lipid layer on damaged skin and for preventing the inhibition of lipid synthesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.