Dosage forms

US6221394A · kind A · utility

Assignee

• Darwin Discovery Limited · GB

Inventors

• Julian Clive Gilbert · St Ives, GB
• Andrew John McGlashan Richards · Cambridge, GB
• Hazel Judith Bardsley · Cambridge, GB

Key dates

• Filing date: Jan 5, 2000
• Grant date: Apr 24, 2001
• Expiry date: Jan 5, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2054
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pharmaceutical dosage form comprises, in one portion thereof, a substantially single (+)-enantiomer of a chiral drug other than verapamil and, in another, separate portion thereof, a substantially single (-)-enantiomer of the drug wherein, in use, the different enantiomers are released at different rates from the dosage form. The dosage form is useful for administration of chiral drugs where both enantiomers have a valid pharmacological input, and where a clinical benefit may be realised by controlling the release rates of those enantiomers. Examples of such drugs include, in particular, tramadol and warfarin.