Controlled release pharmaceutical tablets containing an active principle of low water solubility
US6221395A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 1, 1998 |
| Grant date | Apr 24, 2001 |
| Priority date | — |
| Expiry date | Sep 1, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/4422
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
It is described a new method for the preparation of pharmaceutical tablets carrying poorly soluble in water principle; this method allows to obtain tablets with fast and/or slow release of the active principle. The peculiar feature is the fact that the poorly soluble in water active principle (es: nifedipine) is treated with a surfactant, during the granulation phase or whatever during the preparation process; the obtained product, subjected to a compression, produces pharmaceutical tablets which show high bioavailability of the carried active principle. This procedure can be used to prepare polymeric matrixes (with modified release), formed by tablets with one or more layers. The procedure of manufacture and the characteristics of the new finished tablet are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.