Method of making controlled release particles of complexed polymers

US6221399A · kind A · utility

Assignee

• CSIR · ZA

Inventors

• Heidi Rolfes · Pretoria, ZA
• Thilo Lothar Van Der Merwe · Brakpan, ZA
• Patricia-Ann Truter · Randburg, ZA

Key dates

• Filing date: Jun 1, 1998
• Grant date: Apr 24, 2001
• Expiry date: Jun 1, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/146
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of making a solid interpolymer for use as a controlled release matrix for a controlled release product for oral administration, involves dissolving a first polymer in a solvent therefor, dissolving one or more second complementary polymers capable of complexing with the first polymer to form the interpolymer complex, in a solvent therefor, adding a complexation inhibitor, mixing together the solutions, adjusting the pH if necessary, and spraying the product into a vessel to remove at least partially the solvents and thereby to produce solid particles of the interpolymer complex. An active agent such as a drug is preferably embedded or encapsulated in the interpolymer complex before spray drying or may be incorporated by suitable means at a later stage.