Peptides and compositions which modulate apoptosis
US6221615A · kind A · utility
7Cited by
3References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 25, 1999 |
| Grant date | Apr 24, 2001 |
| Priority date | — |
| Expiry date | Jan 25, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2510/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the "GD domain", which is essential both to Bak's interaction with Bcl-x.sub.L, and to Bak's cell killing function. Methods of identifying agonists or antagonists of GD domain function are provided. The GD domain is responsible for mediating key protein/protein interactions of significance to the actions of multiple cell death regulatory molecules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.