Patent · US Expired

Retinoid suppression of ventricular muscle cell hypertrophy

US6221618A · kind A · utility

2Cited by

1References

5Claims

0Family size

Inventors

Kenneth R. Chien · Cambridge, US
Ming Dong Zhou · Sydney, AU

Key dates

Filing date	Jan 13, 2000
Grant date	Apr 24, 2001
Priority date	—
Expiry date	Jan 13, 2020

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/9453
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention features methods of identifying a compound which suppresses ventricular muscle cell hypertrophy. In one embodiment, ventricular muscle cells are contacted with a test compound, which acts through an RAR or RXR receptor, in the presence of an inducer of hypertrophy. Development of ventricular muscle cell hypertrophy is then measured to identify compounds having the desired activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.