.beta.-secretase antibody

US6221645A · kind A · utility

Assignee

• Elan Pharmaceuticals, Inc. · US

Inventors

• Susanna M. S. Chrysler · Brisbane, US
• Sukanto Sinha · San Francisco, US
• Pamela S. Keim · San Mateo, US
• John P. Anderson · Langenfeld, DE
• Hua Tan · Daly City, US
• Lisa McConlogue · Burlingame, US

Key dates

• Filing date: Jun 7, 1996
• Grant date: Apr 24, 2001
• Expiry date: Jun 7, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Compositions comprising a novel protease capable of cleaving .beta.-amyloid precursor protein (APP) on the amino-terminal side of the .beta.-amyloid peptide therein are provided. The protease is designated .beta.-secretase. Reaction systems comprising .beta.-secretase may be used in screening assays to monitor .beta.-secretase modulated cleavage of APP and to identify .beta.-secretase inhibitors, wherein the .beta.-secretase is in the presence of a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance. Antibodies are raised against peptides of .beta.-secretase. Pharmaceutical compositions and methods comprise compounds identified by screening assays.