Method and apparatus for analysis and sorting of polynucleotides based on size
US6221654A · kind A · utility
330Cited by
48References
46Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 23, 1997 |
| Grant date | Apr 24, 2001 |
| Priority date | — |
| Expiry date | Sep 23, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S366/03
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to a microfabricated device and methods of using the device for analyzing and sorting of single polynucleotides, e.g. by size, according to an optical signal measured within a detection region of the device. An optical signal such as fluorescence from a reporter molecule associated with the polynucleotide molecules can be used to determine polynucleotide size or to direct selected polynucleotides into one or more selected branch channels of the device.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.