Indanyl-substituted benzenecarboxamides, processes for their preparation, their use as a medicament, and pharmaceutical formulations containing them

US6221866A · kind A · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Joachim Brendel · Bad Vilbel, DE
• Uwe Gerlach · Hattersheim, DE
• Hans Ulrich Stilz · Frankfurt am Main, DE
• Hans-Jochen Lang · Hofheim, DE

Key dates

• Filing date: Jun 23, 2000
• Grant date: Apr 24, 2001
• Expiry date: Jun 23, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

##STR1## in which R(1) to R(8) have the meanings stated in the claims, act on the Kv1.5 potassium channel, and inhibit a potassium current, referred to as "ultra-rapidly activating delayed rectifier," in the human atrium. They are therefore very particularly suitable as novel antiarrhythmic active substances, in particular for the treatment and prophylaxis of atrial arrhythmias, e.g., atrial fibrillation or atrial flutter.